Twentyone Hotel is at Via Cola Di Rienzo 23, Rome. Guests rate it 8.3 out of 10 across 5,041 reviews. It is 0.8 miles from Vatican City. Check-in is from 03:00 PM, check-out by 11:00 AM.
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Modern Boutique Hotel on Rome's Best Shopping Street The Twentyone Hotel offers a sleek stay on Via Cola di Rienzo, a prime shopping destination in Rome. Just a short stroll away from iconic landmarks like Castel Sant'Angelo and the historic center, this modern boutique hotel is the perfect blend of style and convenience. Ultra-Modern Rooms and Dining Experience Experience luxury in every detail with ultra-modern rooms boasting minimalist decor and top-notch amenities including LCD satellite TV, air conditioning, minibar, and complimentary WiFi. Indulge in a delightful culinary journey at the on-site restaurant offering traditional Roman and classic Italian dishes paired with a wide selection of wines and champagne. Prime Location in Elegant Prati District Located in the upscale Prati district, the hotel is a stone's throw away from the Vatican and Saint Peter's Basilica, making it an ideal choice for travelers interested in exploring the city's rich history. With easy access to Lepanto Metro Station and bus links to Roma Termini Train Station, your Roman adventure begins at the doorstep of Twentyone Hotel. Book your stay now and elevate your Roman holiday experience at Twentyone Hotel.
Summarised from guest reviews. Scores out of 10.
Please note that parking spaces are limited and subject to availability.
A deposit may be required at the property.
The cheapest month to stay at Twentyone Hotel is January 2027, averaging $163 a night; the most expensive is May 2027 at $312. On average it runs 35% below the Rome hotel average.
| Check-in month | Average per night | Average per night |
|---|---|---|
| November 2026 | $235 | |
| December 2026 | $211 | |
| January 2027Cheapest | $163 | |
| February 2027 | $175 | |
| March 2027 | $233 | |
| April 2027 | $292 | |
| May 2027Most expensive | $312 |
Average nightly room price at this hotel for each check-in date in the next 12 months, in US dollars, as quoted to Fly2Any on October 21, 2026. A planning guide, not a fare: search your dates for live prices.
Check-in at Twentyone Hotel is from 03:00 PM and check-out is by 11:00 AM.
Twentyone Hotel is 14.0 miles from Rome Fiumicino Airport in a straight line; driving distance is longer.
Yes. Vatican City is 0.8 miles from Twentyone Hotel in a straight line.
Guests rate Twentyone Hotel 8.3 out of 10 across 5,041 reviews. They most often mention great location and helpful staff.
Yes. Twentyone Hotel lists free wifi among its amenities. Confirm details with the property for your dates.
Yes. Twentyone Hotel lists an airport shuttle among its amenities. Confirm details with the property for your dates.
Yes. Twentyone Hotel lists a fitness center among its amenities. Confirm details with the property for your dates.
The cheapest month to stay at Twentyone Hotel is January 2027, averaging $163 a night; the most expensive is May 2027 at $312. On average it runs 35% below the Rome hotel average.
